10 Best Ointment For Dry Eyes of 2026

Last updated on 05/15/2026

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Most Relevant

Best Choice

WELMATE Eye Ointment (3 Tubes) - Sodium Chloride Hypertonicity Ophthalmic Ointment 5% - Corneal Edema Relief - Sterile, Non-Greasy - Lanolin & Mineral Oil - 1/8 oz (3.5g) per Tube

WELMATE Eye Ointment (3 Tubes) - Sodium Chloride Hypertonicity Ophthalmic Ointment 5% - Corneal Edema Relief - Sterile, Non-Greasy - Lanolin & Mineral Oil - 1/8 oz (3.5g) per Tube

WELMATE

Why we love it

Effective relief at lower cost.
Easy application for quick relief.
Made in the USA quality.

Main Highlights

Temporary Relief of Corneal Edema – Our 5% Sodium Chloride Ophthalmic Hypertonicity Ointment provides targeted relief for corneal edema and abrasions, helping to soothe and comfort your eyes.
Reliable Results – Delivers the same active ingredient and dosage as found in major corneal edema brands, 5% sodium chloride ophthalmic hypertonicity. Includes 3 eye ointment tubes, 1/8 oz (3.5g).
Expertly Formulated – Our ointment is carefully formulated with lanolin and mineral oil by a team of eye care professionals, ensuring it is both safe and effective for use on the delicate tissues of the eye.
How to Use – To relieve symptoms, pull down the lower lid of the affected eye. Apply a small amount (1/4 inch) of ointment to the inside of the eyelid. Apply every 3 or 4 hours or as directed by a doctor.
Why WELMATE? - Founded in 2020 by former pharmacy employees who were fed up with the pricing of over-the-counter medication. Today, we continue to bring affordable health and wellness products to your doorstep as America's trusted OTC store.

9.8

Exceptional

9.8

Exceptional

WELMATE

WELMATE Eye Ointment (3 Tubes) - Sodium Chloride Hypertonicity Ophthalmic Ointment 5% - Corneal Edema Relief - Sterile, Non-Greasy - Lanolin & Mineral Oil - 1/8 oz (3.5g) per Tube

Why we love it

Effective relief at lower cost.
Easy application for quick relief.
Made in the USA quality.

Main Highlights

Temporary Relief of Corneal Edema – Our 5% Sodium Chloride Ophthalmic Hypertonicity Ointment provides targeted relief for corneal edema and abrasions, helping to soothe and comfort your eyes.
Reliable Results – Delivers the same active ingredient and dosage as found in major corneal edema brands, 5% sodium chloride ophthalmic hypertonicity. Includes 3 eye ointment tubes, 1/8 oz (3.5g).
Expertly Formulated – Our ointment is carefully formulated with lanolin and mineral oil by a team of eye care professionals, ensuring it is both safe and effective for use on the delicate tissues of the eye.
How to Use – To relieve symptoms, pull down the lower lid of the affected eye. Apply a small amount (1/4 inch) of ointment to the inside of the eyelid. Apply every 3 or 4 hours or as directed by a doctor.
Why WELMATE? - Founded in 2020 by former pharmacy employees who were fed up with the pricing of over-the-counter medication. Today, we continue to bring affordable health and wellness products to your doorstep as America's trusted OTC store.

Value for Money

WELMATE - Eye Ointment (1 Tube) - Sodium Chloride Hypertonicity Ophthalmic Ointment 5% - Relief of Corneal Edema Symptoms - Lanolin & Mineral Oil - Sterile - Travel Size - Eye Care - 1/8 oz (3.5g)

WELMATE - Eye Ointment (1 Tube) - Sodium Chloride Hypertonicity Ophthalmic Ointment 5% - Relief of Corneal Edema Symptoms - Lanolin & Mineral Oil - Sterile - Travel Size - Eye Care - 1/8 oz (3.5g)

WELMATE

Why we love it

Effective relief for corneal edema.
Affordable alternative to prescriptions.
User-friendly application process.

Main Highlights

Temporary Relief of Corneal Edema – Our 5% Sodium Chloride Ophthalmic Hypertonicity Ointment provides targeted relief for corneal edema and abrasions, helping to soothe and comfort your eyes.
Reliable Results – Delivers the same active ingredient and dosage as found in major corneal edema brands, 5% sodium chloride ophthalmic hypertonicity. Includes 1 eye ointment tube, 1/8 oz (3.5g).
Expertly Formulated – Our ointment is carefully formulated with lanolin and mineral oil by a team of eye care professionals, ensuring it is both safe and effective for use on the delicate tissues of the eye.
How to Use – To relieve symptoms, pull down the lower lid of the affected eye. Apply a small amount (1/4 inch) of ointment to the inside of the eyelid. Apply every 3 or 4 hours or as directed by a doctor.
Why WELMATE? - Founded in 2020 by former pharmacy employees who were fed up with the pricing of over-the-counter medication. Today, we continue to bring affordable health and wellness products to your doorstep as America's trusted OTC store.

WELMATE - Eye Ointment (1 Tube) - Sodium Chloride Hypertonicity Ophthalmic Ointment 5% - Relief of Corneal Edema Symptoms - Lanolin & Mineral Oil - Sterile - Travel Size - Eye Care - 1/8 oz (3.5g)

Why we love it

Effective relief for corneal edema.
Affordable alternative to prescriptions.
User-friendly application process.

Main Highlights

Temporary Relief of Corneal Edema – Our 5% Sodium Chloride Ophthalmic Hypertonicity Ointment provides targeted relief for corneal edema and abrasions, helping to soothe and comfort your eyes.
Reliable Results – Delivers the same active ingredient and dosage as found in major corneal edema brands, 5% sodium chloride ophthalmic hypertonicity. Includes 1 eye ointment tube, 1/8 oz (3.5g).
Expertly Formulated – Our ointment is carefully formulated with lanolin and mineral oil by a team of eye care professionals, ensuring it is both safe and effective for use on the delicate tissues of the eye.
How to Use – To relieve symptoms, pull down the lower lid of the affected eye. Apply a small amount (1/4 inch) of ointment to the inside of the eyelid. Apply every 3 or 4 hours or as directed by a doctor.
Why WELMATE? - Founded in 2020 by former pharmacy employees who were fed up with the pricing of over-the-counter medication. Today, we continue to bring affordable health and wellness products to your doorstep as America's trusted OTC store.

Systane Lub Eye Nightime Ointment 3.5g (6 Pack) 0.12 Ounce(Packaging May Vary)

Systane Lub Eye Nightime Ointment 3.5g (6 Pack) 0.12 Ounce(Packaging May Vary)

Systane

Why we love it

Gentle on the skin.
Highly moisturizing formula.
Compact and travel-friendly packaging.

Main Highlights

Item Package Length: 8.001cm
Item Package Width: 10.210cm
Item Package Height: 13.208cm
Ingredients: Active Ingredients: Mineral Oil (3%). White Petrolatum (94%). Inactive Ingredients: Anhydrous Liquid Lanolin (3%).

Systane Lub Eye Nightime Ointment 3.5g (6 Pack) 0.12 Ounce(Packaging May Vary)

Why we love it

Gentle on the skin.
Highly moisturizing formula.
Compact and travel-friendly packaging.

Main Highlights

Item Package Length: 8.001cm
Item Package Width: 10.210cm
Item Package Height: 13.208cm
Ingredients: Active Ingredients: Mineral Oil (3%). White Petrolatum (94%). Inactive Ingredients: Anhydrous Liquid Lanolin (3%).

Genteal Pm Dry Eye Relief Severe Night-Time Ointment .12 fl oz (4 Pack)

Genteal Pm Dry Eye Relief Severe Night-Time Ointment .12 fl oz (4 Pack)

Rugby Sodium Chloride Hypertonicity Ophthalmic Ointment 5% - 50 mg Sodium Chloride Eye Ointment for Temporary Corneal Edema Relief - Made With Lanolin and Mineral Oil - Alcohol-Free - 0.125 Oz(3 Pack)

Rugby Sodium Chloride Hypertonicity Ophthalmic Ointment 5% - 50 mg Sodium Chloride Eye Ointment for Temporary Corneal Edema Relief - Made With Lanolin and Mineral Oil - Alcohol-Free - 0.125 Oz(3 Pack)

RUGBY LABORATORIES

Why we love it

Effective relief for corneal edema.
Quality ingredients for safe use.
Trusted and accessible wellness solution.

Main Highlights

RELIEVES CORNEAL EDEMA: Introducing Rugby's Sodium Chloride Hypertonicity Ophthalmic Ointment, a trusted remedy for temporary relief from corneal edema.
INGREDIENTS: Our eye ointment is made with 50 mg of Sodium Chloride, lanolin, mineral oil, purified water, and white petrolatum. It is free from alcohol, gluten, latex, peanuts, soy, and sugar.
QUALITY FORMULATION: We maintain high standards of care through strict regulatory compliance to deliver carefully formulated, effective eye ointment. With a 5% sodium chloride formula, our eye ointment helps provide temporary relief from corneal edema.
HOW TO USE: Pull down the lower lid of the affected eye(s) and apply a small amount (about 0.25 inch) of the ointment to the inside of the eyelid. Apply every 3 to 4 hours. It may cause temporary burning. Stop use if the condition persists for more than 72 hours.
RUGBY LABORATORIES: At Rugby Laboratories, we believe wellness should be accessible to everyone. We pride ourselves on our legacy of delivering quality OTC and vitamin supplements.

Rugby Sodium Chloride Hypertonicity Ophthalmic Ointment 5% - 50 mg Sodium Chloride Eye Ointment for Temporary Corneal Edema Relief - Made With Lanolin and Mineral Oil - Alcohol-Free - 0.125 Oz(3 Pack)

Why we love it

Effective relief for corneal edema.
Quality ingredients for safe use.
Trusted and accessible wellness solution.

Main Highlights

RELIEVES CORNEAL EDEMA: Introducing Rugby's Sodium Chloride Hypertonicity Ophthalmic Ointment, a trusted remedy for temporary relief from corneal edema.
INGREDIENTS: Our eye ointment is made with 50 mg of Sodium Chloride, lanolin, mineral oil, purified water, and white petrolatum. It is free from alcohol, gluten, latex, peanuts, soy, and sugar.
QUALITY FORMULATION: We maintain high standards of care through strict regulatory compliance to deliver carefully formulated, effective eye ointment. With a 5% sodium chloride formula, our eye ointment helps provide temporary relief from corneal edema.
HOW TO USE: Pull down the lower lid of the affected eye(s) and apply a small amount (about 0.25 inch) of the ointment to the inside of the eyelid. Apply every 3 to 4 hours. It may cause temporary burning. Stop use if the condition persists for more than 72 hours.
RUGBY LABORATORIES: At Rugby Laboratories, we believe wellness should be accessible to everyone. We pride ourselves on our legacy of delivering quality OTC and vitamin supplements.

Optase HYLO® Night Eye Ointment, 0.18 oz - Phosphate & Preservative-Free Dry Eye Relief for Overnight Comfort - Well-Tolerated Formula, Long-Lasting Lubricating Nighttime Ointment for Dry Eyes

Optase HYLO® Night Eye Ointment, 0.18 oz - Phosphate & Preservative-Free Dry Eye Relief for Overnight Comfort - Well-Tolerated Formula, Long-Lasting Lubricating Nighttime Ointment for Dry Eyes

Optase

Why we love it

Preservative free formula.
Long lasting overnight relief.
Gentle on sensitive skin.

Main Highlights

NIGHTTIME DRY EYE COMFORT: Lubricating eye ointment for dry eyes that helps provide overnight comfort, in a well-tolerated nighttime formula designed for lasting lubrication while you sleep
LONG-LASTING RELIEF: Preservative-free nighttime formula provides over 6 hours of physical retention to help support overnight comfort and lasting lubrication for dry eyes through the night
GENTLE OVERNIGHT LUBRICATION: White Petrolatum, Lanolin, and Light Mineral Oil create a smooth lubricating film for lasting nighttime comfort, with a formula suitable for all ages.
OVERNIGHT EYE CARE ROUTINE: For nighttime comfort, apply once into the gap between the eye and eyelid before bed, then blink gently to spread the ointment for lasting lubrication. Use only as directed
OPTASE EXPERTISE: Part of the OPTASE Eye Care Regimen, developed for dry eye care with specialist- informed, preservative-free products that support comfort, protection, and daily eye care

Optase HYLO® Night Eye Ointment, 0.18 oz - Phosphate & Preservative-Free Dry Eye Relief for Overnight Comfort - Well-Tolerated Formula, Long-Lasting Lubricating Nighttime Ointment for Dry Eyes

Why we love it

Preservative free formula.
Long lasting overnight relief.
Gentle on sensitive skin.

Main Highlights

NIGHTTIME DRY EYE COMFORT: Lubricating eye ointment for dry eyes that helps provide overnight comfort, in a well-tolerated nighttime formula designed for lasting lubrication while you sleep
LONG-LASTING RELIEF: Preservative-free nighttime formula provides over 6 hours of physical retention to help support overnight comfort and lasting lubrication for dry eyes through the night
GENTLE OVERNIGHT LUBRICATION: White Petrolatum, Lanolin, and Light Mineral Oil create a smooth lubricating film for lasting nighttime comfort, with a formula suitable for all ages.
OVERNIGHT EYE CARE ROUTINE: For nighttime comfort, apply once into the gap between the eye and eyelid before bed, then blink gently to spread the ointment for lasting lubrication. Use only as directed
OPTASE EXPERTISE: Part of the OPTASE Eye Care Regimen, developed for dry eye care with specialist- informed, preservative-free products that support comfort, protection, and daily eye care

Systane Lub Eye Nightime Ointment 3.5g (2 Pack) 0.12 Ounce

Systane Lub Eye Nightime Ointment 3.5g (2 Pack) 0.12 Ounce

Systane

Why we love it

Versatile pack of two.
Skin nourishing ingredients.
Moisturizes and protects effectively.

Main Highlights

Pack of 2
Ingredients: Active Ingredients: Mineral Oil (3%). White Petrolatum (94%). Inactive Ingredients: Anhydrous Liquid Lanolin (3%).

Systane Lub Eye Nightime Ointment 3.5g (2 Pack) 0.12 Ounce

Why we love it

Versatile pack of two.
Skin nourishing ingredients.
Moisturizes and protects effectively.

Main Highlights

Pack of 2
Ingredients: Active Ingredients: Mineral Oil (3%). White Petrolatum (94%). Inactive Ingredients: Anhydrous Liquid Lanolin (3%).

Systane Nighttime Eye Ointment for Dry Eyes (2 Pack)

Systane Nighttime Eye Ointment for Dry Eyes (2 Pack)

Systane

Why we love it

Restores comfort while sleeping.
Long-lasting dry eye relief.
Safe, preservative-free formula.

Main Highlights

Long-Lasting Overnight Relief: Provides extended relief for severe dry eye symptoms throughout the night
Protective Moisture Barrier: Forms a protective moisture-sealing barrier while you sleep to lock in hydration
Soothing Comfort: Helps soothe burning, irritation, and dryness associated with dry eye conditions
Extended Nighttime Hydration: Suitable for chronic dry eye or those requiring extended nighttime moisture protection
Gentle Formula: Safe and gentle petroleum-based formula suitable for sensitive eyes
Convenient Two Pack: Includes two tubes of ointment for extended use and value

Systane Nighttime Eye Ointment for Dry Eyes (2 Pack)

Why we love it

Restores comfort while sleeping.
Long-lasting dry eye relief.
Safe, preservative-free formula.

Main Highlights

Long-Lasting Overnight Relief: Provides extended relief for severe dry eye symptoms throughout the night
Protective Moisture Barrier: Forms a protective moisture-sealing barrier while you sleep to lock in hydration
Soothing Comfort: Helps soothe burning, irritation, and dryness associated with dry eye conditions
Extended Nighttime Hydration: Suitable for chronic dry eye or those requiring extended nighttime moisture protection
Gentle Formula: Safe and gentle petroleum-based formula suitable for sensitive eyes
Convenient Two Pack: Includes two tubes of ointment for extended use and value

Soothe Preservative-Free Lubricant Eye Ointment, Nighttime Relief for Severe Dry & Irritated Eyes, Gentle for Sensitive Eyes, 0.12 Fl Oz

Soothe Preservative-Free Lubricant Eye Ointment, Nighttime Relief for Severe Dry & Irritated Eyes, Gentle for Sensitive Eyes, 0.12 Fl Oz

Soothe

Why we love it

Moisturizes severe dry eyes overnight.
Gentle formula for sensitive eyes.
Trusted brand with 150 years experience.

Main Highlights

EYE OINTMENT FOR DRY EYES AT NIGHT: Use Soothe Lubricant Eye Ointment to help moisturize & refresh severe dry eyes overnight for long-lasting relief & comfort. Soothing nighttime dry eye relief formula to help relieve dryness & prevent irritation
SEVERE DRY EYE RELIEF: This dry eye ointment contains two lubricants to help relieve dry and irritated eye symptoms. Soothe ointment is gentle enough for sensitive eyes and can be used as often as needed, but stop use and ask a doctor if condition worsens or persists more than 72 hours. Remove contact lenses before using
BAUSCH +LOMB EYE DROPS: Whether you have dry eyes, red eyes, itchy eyes, or all of the above, we offer a variety of options for your needs, including lubricating & preservative-free eye drops
EYE CARE EXPERTS: For over 150 years, Bausch + Lomb has focused on innovation & quality in our eye care products, from contact lenses & solutions to eye drops, ointments, eye vitamins & more
EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, & ointments to help make sure your eyes feel healthy, moisturized, & protected

Soothe Preservative-Free Lubricant Eye Ointment, Nighttime Relief for Severe Dry & Irritated Eyes, Gentle for Sensitive Eyes, 0.12 Fl Oz

Why we love it

Moisturizes severe dry eyes overnight.
Gentle formula for sensitive eyes.
Trusted brand with 150 years experience.

Main Highlights

EYE OINTMENT FOR DRY EYES AT NIGHT: Use Soothe Lubricant Eye Ointment to help moisturize & refresh severe dry eyes overnight for long-lasting relief & comfort. Soothing nighttime dry eye relief formula to help relieve dryness & prevent irritation
SEVERE DRY EYE RELIEF: This dry eye ointment contains two lubricants to help relieve dry and irritated eye symptoms. Soothe ointment is gentle enough for sensitive eyes and can be used as often as needed, but stop use and ask a doctor if condition worsens or persists more than 72 hours. Remove contact lenses before using
BAUSCH +LOMB EYE DROPS: Whether you have dry eyes, red eyes, itchy eyes, or all of the above, we offer a variety of options for your needs, including lubricating & preservative-free eye drops
EYE CARE EXPERTS: For over 150 years, Bausch + Lomb has focused on innovation & quality in our eye care products, from contact lenses & solutions to eye drops, ointments, eye vitamins & more
EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, & ointments to help make sure your eyes feel healthy, moisturized, & protected