10 Best Otc Sinus Decongestant of 2026

Last updated on 06/10/2026

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Most Relevant

Best Choice

Vicks Sinex Severe Allergy & Sinus Nasal Spray, Original Ultra Fine Mist, Decongestant Relief from Nasal Congestion, Sinus Pressure Relief, 265 Sprays (2 Count)

Vicks Sinex Severe Allergy & Sinus Nasal Spray, Original Ultra Fine Mist, Decongestant Relief from Nasal Congestion, Sinus Pressure Relief, 265 Sprays (2 Count)

Vicks

Why we love it

Targets nasal congestion effectively.
Provides 12-hour relief.
HSA and FSA eligible.

Main Highlights

Targets nasal congestion and sinus pressure at the source by reducing swelling in the sinuses
Breathe better all day or all night long with Vicks Sinex Severe. For instant, 12-hour, nasal congestion and sinus pressure relief
This powerful decongestant medicine be used to treat severe sinus congestion and pressure caused by a cold or seasonal allergy spell, Not intended for daily use
Unlike nasal decongestant tablets, Vicks Sinex Severe Nasal Sprays works by delivering powerful decongestant medicine directly to your nasal membranes
Vicks Sinex Severe Nasal Spray is HSA and FSA eligible, Check with your provider for more details

9.8

Exceptional

9.8

Exceptional

Vicks

Vicks Sinex Severe Allergy & Sinus Nasal Spray, Original Ultra Fine Mist, Decongestant Relief from Nasal Congestion, Sinus Pressure Relief, 265 Sprays (2 Count)

Why we love it

Targets nasal congestion effectively.
Provides 12-hour relief.
HSA and FSA eligible.

Main Highlights

Targets nasal congestion and sinus pressure at the source by reducing swelling in the sinuses
Breathe better all day or all night long with Vicks Sinex Severe. For instant, 12-hour, nasal congestion and sinus pressure relief
This powerful decongestant medicine be used to treat severe sinus congestion and pressure caused by a cold or seasonal allergy spell, Not intended for daily use
Unlike nasal decongestant tablets, Vicks Sinex Severe Nasal Sprays works by delivering powerful decongestant medicine directly to your nasal membranes
Vicks Sinex Severe Nasal Spray is HSA and FSA eligible, Check with your provider for more details

Value for Money

Sudafed OM Sinus Severe No Drip Nasal Spray with Cooling Menthol, Maximum Strength Sinus Decongestant for Fast Congestion & Pressure Relief, Oxymetazoline HCl .05% Nose Spray, 1 fl. oz

Sudafed OM Sinus Severe No Drip Nasal Spray with Cooling Menthol, Maximum Strength Sinus Decongestant for Fast Congestion & Pressure Relief, Oxymetazoline HCl .05% Nose Spray, 1 fl. oz

Sudafed

Why we love it

Fast relief in seconds.
No drip spray.
Relief lasts twelve hours.

Main Highlights

1-fluid ounce spray bottle of maximum strength Sudafed OM Sinus Severe No Drip Nasal Spray that starts to work in seconds for fast-acting, powerful sinus and nasal congestion relief that lasts up to 12 hours
This nasal spray decongestant provides fast, powerful congestion relief due to the common cold and allergies. It temporarily relieves sinus pressure caused by hay fever or colds and shrinks swollen nasal passages so you can breathe more freely
The fast-acting, no drip spray is formulated with 0.05% oxymetazoline HCl, a powerful nasal decongestant, to relieve annoying nasal congestion symptoms and clear stuffy noses so you can breathe easier
For adults and children over the age of six, dispense two to three sprays in each nostril, not more often than every 10 to 12 hours for relief from bothersome severe sinus congestion. Do not use for more than three days; use only as directed
Breathe easier with Sudafed OM Sinus Severe No Drip Nasal Spray with Cooling Menthol, the sinus spray that sprays and stays. Fast, over-the-counter 12-hour nasal congestion relief from the #1 pharmacist-recommended oral OTC decongestant brand

Sudafed OM Sinus Severe No Drip Nasal Spray with Cooling Menthol, Maximum Strength Sinus Decongestant for Fast Congestion & Pressure Relief, Oxymetazoline HCl .05% Nose Spray, 1 fl. oz

Why we love it

Fast relief in seconds.
No drip spray.
Relief lasts twelve hours.

Main Highlights

1-fluid ounce spray bottle of maximum strength Sudafed OM Sinus Severe No Drip Nasal Spray that starts to work in seconds for fast-acting, powerful sinus and nasal congestion relief that lasts up to 12 hours
This nasal spray decongestant provides fast, powerful congestion relief due to the common cold and allergies. It temporarily relieves sinus pressure caused by hay fever or colds and shrinks swollen nasal passages so you can breathe more freely
The fast-acting, no drip spray is formulated with 0.05% oxymetazoline HCl, a powerful nasal decongestant, to relieve annoying nasal congestion symptoms and clear stuffy noses so you can breathe easier
For adults and children over the age of six, dispense two to three sprays in each nostril, not more often than every 10 to 12 hours for relief from bothersome severe sinus congestion. Do not use for more than three days; use only as directed
Breathe easier with Sudafed OM Sinus Severe No Drip Nasal Spray with Cooling Menthol, the sinus spray that sprays and stays. Fast, over-the-counter 12-hour nasal congestion relief from the #1 pharmacist-recommended oral OTC decongestant brand

Sudafed, PE Sinus Congestion Relief Tablets, Maximum Strength, Non-Drowsy 10 mg Phenylephrine HCI Decongestant for Sinus Pressure and Nasal Congestion Relief, Due to Cold or Allergies, 36 Count

Sudafed, PE Sinus Congestion Relief Tablets, Maximum Strength, Non-Drowsy 10 mg Phenylephrine HCI Decongestant for Sinus Pressure and Nasal Congestion Relief, Due to Cold or Allergies, 36 Count

Sudafed

27% Off

Why we love it

Fast sinus pressure relief.
Non-drowsy symptom management.
Pharmacist recommended choice.

Main Highlights

Sinus pressure & congestion relief: 36-count package of Sudafed PE sinus congestion maximum strength; a non-drowsy decongestant tablet for fast and relief of sinus pressure and sinus and nasal congestion
Non-drowsy cold & sinus medicine: Sudafed sinus congestion and cold relief medication helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies and the common cold
Phenylephrine HCl formula: each sinus pressure relief tablet has 10 mg of phenylephrine HCl, a nasal decongestant to provide fast symptom relief; it reduces nasal swelling to help you breathe easier
How to use: Sudafed PE sinus congestion tablets can be used by adults and children ages 12 and up; take one nasal decongestant tablet every four hours; do not exceed six tablets within a 24 hour time period
FSA HSA approved product**: Sinus pressure due to cold and allergies medicine from Sudafed, the #1 pharmacist recommended brand among oral OTC decongestants. ** Check your plan for details as plans may vary.

Sudafed, PE Sinus Congestion Relief Tablets, Maximum Strength, Non-Drowsy 10 mg Phenylephrine HCI Decongestant for Sinus Pressure and Nasal Congestion Relief, Due to Cold or Allergies, 36 Count

27% Off

Why we love it

Fast sinus pressure relief.
Non-drowsy symptom management.
Pharmacist recommended choice.

Main Highlights

Sinus pressure & congestion relief: 36-count package of Sudafed PE sinus congestion maximum strength; a non-drowsy decongestant tablet for fast and relief of sinus pressure and sinus and nasal congestion
Non-drowsy cold & sinus medicine: Sudafed sinus congestion and cold relief medication helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies and the common cold
Phenylephrine HCl formula: each sinus pressure relief tablet has 10 mg of phenylephrine HCl, a nasal decongestant to provide fast symptom relief; it reduces nasal swelling to help you breathe easier
How to use: Sudafed PE sinus congestion tablets can be used by adults and children ages 12 and up; take one nasal decongestant tablet every four hours; do not exceed six tablets within a 24 hour time period
FSA HSA approved product**: Sinus pressure due to cold and allergies medicine from Sudafed, the #1 pharmacist recommended brand among oral OTC decongestants. ** Check your plan for details as plans may vary.

Mucinex Nightshift Sinus, Cold And Flu Cough Medicine For Adults, Powerful Nighttime Sinus Medicine For Sinus Relief, Sore Throat Relief, Cough Suppressant & Nasal Decongestant For Adults, 6 Fl Oz

Mucinex Nightshift Sinus, Cold And Flu Cough Medicine For Adults, Powerful Nighttime Sinus Medicine For Sinus Relief, Sore Throat Relief, Cough Suppressant & Nasal Decongestant For Adults, 6 Fl Oz

Mucinex

Why we love it

Relieves fever and sneezing effectively.
Controls persistent cough easily.
Soothes sore throat and congestion.

Main Highlights

COUGH MEDICINE ADULTS: Tackle nighttime coughing woes head-on with Mucinex Nightshift Sinus; This liquid formula helps to relieve your worst nighttime sinus and nasal congestion symptoms, so you can wake up ready to conquer the day
COLD MEDICINE: Find relief from fever, headache, minor aches, sore throat, cough, sneezing, and runny nose with Mucinex Nightshift Sinus—a powerful liquid formula designed to tackle nighttime sinus symptoms effectively
NIGHTTIME COLD AND FLU SYMPTOM RELIEF: Mucinex Nightshift Sinus helps to reduce fever, relieve headache, minor aches and pains, sore throat, coughing, sneezing, runny nose for a better morning
SINUS RELIEF + SORE THROAT RELIEF: Mucinex Nightshift is a powerful sinus medicine that provides sinus relief & sore throat relief; Contains Acetaminophen which helps reduce fever & relieves minor aches & pains including sore throat pain
MUCINEX NIGHTSHIFT SINUS ACTIVE INGREDIENTS: Contains Acetaminophen - Pain reliever and fever reducer; Dextromethorphan HBr - Cough suppressant; Phenylephrine HCl - Nasal Decongestant; Triprolidine HCl – Antihistamine
USAGE: Use as directed; For ages 12+ years

Mucinex Nightshift Sinus, Cold And Flu Cough Medicine For Adults, Powerful Nighttime Sinus Medicine For Sinus Relief, Sore Throat Relief, Cough Suppressant & Nasal Decongestant For Adults, 6 Fl Oz

Why we love it

Relieves fever and sneezing effectively.
Controls persistent cough easily.
Soothes sore throat and congestion.

Main Highlights

COUGH MEDICINE ADULTS: Tackle nighttime coughing woes head-on with Mucinex Nightshift Sinus; This liquid formula helps to relieve your worst nighttime sinus and nasal congestion symptoms, so you can wake up ready to conquer the day
COLD MEDICINE: Find relief from fever, headache, minor aches, sore throat, cough, sneezing, and runny nose with Mucinex Nightshift Sinus—a powerful liquid formula designed to tackle nighttime sinus symptoms effectively
NIGHTTIME COLD AND FLU SYMPTOM RELIEF: Mucinex Nightshift Sinus helps to reduce fever, relieve headache, minor aches and pains, sore throat, coughing, sneezing, runny nose for a better morning
SINUS RELIEF + SORE THROAT RELIEF: Mucinex Nightshift is a powerful sinus medicine that provides sinus relief & sore throat relief; Contains Acetaminophen which helps reduce fever & relieves minor aches & pains including sore throat pain
MUCINEX NIGHTSHIFT SINUS ACTIVE INGREDIENTS: Contains Acetaminophen - Pain reliever and fever reducer; Dextromethorphan HBr - Cough suppressant; Phenylephrine HCl - Nasal Decongestant; Triprolidine HCl – Antihistamine
USAGE: Use as directed; For ages 12+ years

Medi-First Sinus Decongestant

PS Medical

20% Off

Why we love it

Relieves nasal congestion temporarily.
Contains phenylephrine HCL 10mg.
Easy to swallow tablets.

Main Highlights

Helps temporarily relieve nasal congestion due to the common cold, hay fever or other upper respiratory allergies
The sinus decongestant is formulated with active ingredient, phenylephrine HCL (10mg)
The easy-to-swallow, film coated tablets help relieve sinus congestion and pressure
Country of origin: Canada

Medi-First Sinus Decongestant

20% Off

Why we love it

Relieves nasal congestion temporarily.
Contains phenylephrine HCL 10mg.
Easy to swallow tablets.

Main Highlights

Helps temporarily relieve nasal congestion due to the common cold, hay fever or other upper respiratory allergies
The sinus decongestant is formulated with active ingredient, phenylephrine HCL (10mg)
The easy-to-swallow, film coated tablets help relieve sinus congestion and pressure
Country of origin: Canada

HealthA2Z® Decongestant PE | Phenylephrine HCl 5 mg | Nasal & Sinus Congestion Relief Due to Cold & Allergies (300 Count, 5mg)

HealthA2Z® Decongestant PE | Phenylephrine HCl 5 mg | Nasal & Sinus Congestion Relief Due to Cold & Allergies (300 Count, 5mg)

HealthA2Z® Decongestant PE | Phenylephrine HCl 5 mg | Nasal & Sinus Congestion Relief Due to Cold & Allergies (300 Count, 5mg)

PhysiciansCare Sinus Decongestant Congestion Medication, 2 Tablets Per Packet, Box Of 50

PhysiciansCare Sinus Decongestant Congestion Medication, 2 Tablets Per Packet, Box Of 50

PhysiciansCare

7% Off

Why we love it

Effective sinus relief solution.
Convenient single-tablet packaging.
Non-drowsy, easy-to-swallow formula.

Main Highlights

Compare to the active ingredients in Sudafed PE
Coated, easy-to-swallow tablets.
50 single-tablet packets come in a perforated dispenser box for easy access.
Relieves sinus pressure and congestion.
Non-drowsy formula.

PhysiciansCare Sinus Decongestant Congestion Medication, 2 Tablets Per Packet, Box Of 50

7% Off

Why we love it

Effective sinus relief solution.
Convenient single-tablet packaging.
Non-drowsy, easy-to-swallow formula.

Main Highlights

Compare to the active ingredients in Sudafed PE
Coated, easy-to-swallow tablets.
50 single-tablet packets come in a perforated dispenser box for easy access.
Relieves sinus pressure and congestion.
Non-drowsy formula.

Sudafed PE Sinus Pressure Relief Plus Pain Relief Tablets, Maximum Strength, Non-Drowsy Decongestant, OTC Sinus Medicine with Acetaminophen and Phenylephrine HCl Nasal Decongestant, 24 CT

Sudafed PE Sinus Pressure Relief Plus Pain Relief Tablets, Maximum Strength, Non-Drowsy Decongestant, OTC Sinus Medicine with Acetaminophen and Phenylephrine HCl Nasal Decongestant, 24 CT

Sudafed

15% Off

Why we love it

Fast relief from sinus pressure.
Non-drowsy formula for daily use.
Pharmacist recommended for effectiveness.

Main Highlights

DECONGESTANT & PAIN RELIEF: 24-count package of Sudafed PE Sinus Pressure and Pain maximum strength non-drowsy decongestant tablets for fast and powerful relief of sinus congestion, sinus pressure, and nasal congestion
NON-DROWSY COLD and SINUS MEDICINE: Sudafed sinus and pain medication helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies and the common cold, plus sinus headaches
PHENYLEPHRINE HCL & ACETAMINOPHEN: Each sinus congestion and pressure relief tablet contains 5 mg of phenylephrine HCI, a nasal decongestant for non-drowsy relief, plus, 325 mg of acetaminophen, a pain & fever reducer
HOW TO USE: Sudafed PE sinus pressure and pain relief congestion relief tablets can be used by adults and children ages 12 and up. Take two tablets every four hours; do not exceed 10 tablets within a 24 hour time
FSA HSA APPROVED PRODUCT: Sinus congestion relief & pain medicine from Sudafed, the #1 pharmacist recommended brand among oral OTC decongestants. Sudafed PE Sinus Pressure + Pain is HSA & FSA eligible** **Check your plan for details as plans may vary.

Sudafed PE Sinus Pressure Relief Plus Pain Relief Tablets, Maximum Strength, Non-Drowsy Decongestant, OTC Sinus Medicine with Acetaminophen and Phenylephrine HCl Nasal Decongestant, 24 CT

15% Off

Why we love it

Fast relief from sinus pressure.
Non-drowsy formula for daily use.
Pharmacist recommended for effectiveness.

Main Highlights

DECONGESTANT & PAIN RELIEF: 24-count package of Sudafed PE Sinus Pressure and Pain maximum strength non-drowsy decongestant tablets for fast and powerful relief of sinus congestion, sinus pressure, and nasal congestion
NON-DROWSY COLD and SINUS MEDICINE: Sudafed sinus and pain medication helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies and the common cold, plus sinus headaches
PHENYLEPHRINE HCL & ACETAMINOPHEN: Each sinus congestion and pressure relief tablet contains 5 mg of phenylephrine HCI, a nasal decongestant for non-drowsy relief, plus, 325 mg of acetaminophen, a pain & fever reducer
HOW TO USE: Sudafed PE sinus pressure and pain relief congestion relief tablets can be used by adults and children ages 12 and up. Take two tablets every four hours; do not exceed 10 tablets within a 24 hour time
FSA HSA APPROVED PRODUCT: Sinus congestion relief & pain medicine from Sudafed, the #1 pharmacist recommended brand among oral OTC decongestants. Sudafed PE Sinus Pressure + Pain is HSA & FSA eligible** **Check your plan for details as plans may vary.

HealthA2Z® Decongestant PE | Phenylephrine HCl 10 mg | Nasal & Sinus Congestion Relief Due to Cold & Allergies (300 Count (Pack of 1))

HealthA2Z® Decongestant PE | Phenylephrine HCl 10 mg | Nasal & Sinus Congestion Relief Due to Cold & Allergies (300 Count (Pack of 1))

HealthA2Z

50% Off

Why we love it

Powerful nasal decongestant relief.
Great value with 300 tablets.
Fast-acting for quick comfort.

Main Highlights

🔴 Powerful Nasal Decongestant: Each tablet contains Phenylephrine HCl 10 mg, an effective nasal decongestant that provides temporary relief from nasal and sinus congestion due to colds, hay fever, or upper respiratory allergies.
🔴 Great Value Supply: Includes 300 tablets per bottle — a long-lasting supply ideal for home, office, or travel medicine cabinets.
🔴 Fast-Acting Relief: Helps open up nasal passages quickly, relieving pressure and congestion so you can focus, rest, or sleep more comfortably.

HealthA2Z® Decongestant PE | Phenylephrine HCl 10 mg | Nasal & Sinus Congestion Relief Due to Cold & Allergies (300 Count (Pack of 1))

50% Off

Why we love it

Powerful nasal decongestant relief.
Great value with 300 tablets.
Fast-acting for quick comfort.

Main Highlights

🔴 Powerful Nasal Decongestant: Each tablet contains Phenylephrine HCl 10 mg, an effective nasal decongestant that provides temporary relief from nasal and sinus congestion due to colds, hay fever, or upper respiratory allergies.
🔴 Great Value Supply: Includes 300 tablets per bottle — a long-lasting supply ideal for home, office, or travel medicine cabinets.
🔴 Fast-Acting Relief: Helps open up nasal passages quickly, relieving pressure and congestion so you can focus, rest, or sleep more comfortably.

Sudafed PE Head Congestion Plus Mucus Relief Tablets for Sinus Pressure, Congestion and Headache, Non-Drowsy Decongestant with Acetaminophen, Guaifenesin, Phenylephrine HCI, 24 ct

Sudafed PE Head Congestion Plus Mucus Relief Tablets for Sinus Pressure, Congestion and Headache, Non-Drowsy Decongestant with Acetaminophen, Guaifenesin, Phenylephrine HCI, 24 ct

Sudafed

8% Off

Why we love it

Non-drowsy congestion relief available.
Effective for sinus pain relief.
Clears mucus for productive coughs.

Main Highlights

24-count box of Sudafed PE: Head Congestion + Mucus Tablets to provide non-drowsy relief from sinus pain and pressure, nasal & chest congestion, and excess mucus
Sinus medicine contains: 5 mg of phenylephrine HCl, a decongestant, for congestion relief and 325 mg of acetaminophen for pain and fever reduction; also 200 mg of guaifenesin, an expectorant for mucus reduction
Head congestion tablets: temporary relieves symptoms associated with hay fever, upper respiratory allergies, and the common cold
Non-drowsy decongestant: tablets provide relief of sinus pressure, headaches, nasal and chest congestion, excess mucus, and minor aches and pains
Head congestion medicine: helps loosen mucus to clear bronchial passageways and make coughs more productive; powerful head congestion relief from the #1 pharmacist recommended brand among oral OTC decongestants.

Sudafed PE Head Congestion Plus Mucus Relief Tablets for Sinus Pressure, Congestion and Headache, Non-Drowsy Decongestant with Acetaminophen, Guaifenesin, Phenylephrine HCI, 24 ct

8% Off

Why we love it

Non-drowsy congestion relief available.
Effective for sinus pain relief.
Clears mucus for productive coughs.

Main Highlights

24-count box of Sudafed PE: Head Congestion + Mucus Tablets to provide non-drowsy relief from sinus pain and pressure, nasal & chest congestion, and excess mucus
Sinus medicine contains: 5 mg of phenylephrine HCl, a decongestant, for congestion relief and 325 mg of acetaminophen for pain and fever reduction; also 200 mg of guaifenesin, an expectorant for mucus reduction
Head congestion tablets: temporary relieves symptoms associated with hay fever, upper respiratory allergies, and the common cold
Non-drowsy decongestant: tablets provide relief of sinus pressure, headaches, nasal and chest congestion, excess mucus, and minor aches and pains
Head congestion medicine: helps loosen mucus to clear bronchial passageways and make coughs more productive; powerful head congestion relief from the #1 pharmacist recommended brand among oral OTC decongestants.